Abstract
The obtained data can be used in the control of various live and inanimate vaccines with a complex composition of ingredients, including prolongators, stabilizers, sorbents, immunostimulants and to clarify the nature of their relationships in the composition of the final product, as well as for the full characteristics of the vaccine used or in the clarification of harmful and harmless, immunogenic, or reactogenic properties in vitro.
Residues capable of preserving in the form of fragments of the initial fibrillar structure of a separate biological substrate included in the vaccine as a biostimulator of a nonspecific immunity factor were identified.
Thus, the study of the morphological composition of biological preparations on the model of a vaccine against avian pasteurellosis with a complex biochemical composition has shown the preservation of many microscopic structures, which allows us to judge the initial components of insoluble particles and detritus or their derivatives after complex biotechnological and biochemical processes in vitro.
The morphological composition of the vaccine substrate was studied using a Leica DM-400B digital microscope.
The inactivated vaccines against avian pasteurellosis that exist to date have not been tested and studied, with the exception of the inactivated vaccine against avian pasteurellosis proposed by the authors M.Umitzhanov, K.Zh.Kushaliev et. al. .
In other cases, we do not have the opportunity to talk about the preservation of microscopic structures of the inactivated vaccine proposed by other authors. This applies to the following biological preparations, in particular to the developed vaccines Gusev A.A., Rusaleev V.S., Sosnitsky A.I., Gnevashev V.M., Pruntova O.V.; Borodina O.V.; Leonova A.V.; Rozhdestvenskaya T.N.; Novikova O.B. For the above-mentioned inactivated vaccines, the authors do not describe morphologically the composition, but only provide information on their effectiveness.
01 Introduction
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02 References
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